A white squiggly protein and a green squiggly protein, with an arrow pointing down, indicating that a piece of the green protein is interacting with the white protein Department of Biology researchers developed a computational method, FragFold, to systematically predict which protein fragments may inhibit a target protein’s function. The image shows an example of one of the interactions the researchers explored: a protein complex between lipopolysaccharide transport proteins LptF (white) and LptG (green). The protein fragment of LptG (red) inhibits this interaction, disrupting the delivery of lipopolysaccharide, a crucial component of the E. coli outer cell membrane essential for cellular fitness. Credits: Image courtesy of Andrew Savinov. All biological function is dependent on how different proteins interact with each other. Protein-protein interactions facilitate everything from transcribing DNA and […]
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